Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin

BACKGROUND: ERCC1, a component of nucleotide excision repair pathway, is known to repair DNA breaks induced by platinum drugs. We sought to ascertain if ERCC1 expression dynamics and a single nucleotide polymorphism (SNP) rs11615 are biomarkers of sensitivity to oxaliplatin therapy in patients with...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Rao, Devika, Mallick, Atrayee Basu, Augustine, Titto, Daroqui, Cecilia, Jiffry, Jeeshan, Merla, Amartej, Chaudhary, Imran, Seetharam, Raviraja, Sood, Arjun, Gajavelli, Srikanth, Aparo, Santiago, Rajdev, Lakshmi, Kaubisch, Andreas, Chuy, Jennifer, Negassa, Abdissa, Mariadason, John M., Maitra, Radhashree, Goel, Sanjay
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756860/
https://ncbi.nlm.nih.gov/pubmed/31565185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27140
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