The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment

In the tumor microenvironment (TME) ATP and its receptor P2X7 exert a pivotal influence on cancer growth and tumor–host interactions. Here we analyzed the different effect of P2X7 genetic deficiency versus its antagonism on response against P2X7-expressing implanted tumors. We focused on immune cell...

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Detalles Bibliográficos
Publicado en:Oncogene
Main Authors: De Marchi, Elena, Orioli, Elisa, Pegoraro, Anna, Sangaletti, Sabina, Portararo, Paola, Curti, Antonio, Colombo, Mario Paolo, Di Virgilio, Francesco, Adinolfi, Elena
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756114/
https://ncbi.nlm.nih.gov/pubmed/30655604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0684-y
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