ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells

Chemotherapy-induced immunogenic cell death can favor dendritic cell (DC) cross-priming of tumor-associated antigens for T cell activation thanks to the release of damage-associated molecular patterns, including ATP. Here, we tested the hypothesis that in acute myeloid leukemia (AML), ATP release, a...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lecciso, Mariangela, Ocadlikova, Darina, Sangaletti, Sabina, Trabanelli, Sara, De Marchi, Elena, Orioli, Elisa, Pegoraro, Anna, Portararo, Paola, Jandus, Camilla, Bontadini, Andrea, Redavid, Annarita, Salvestrini, Valentina, Romero, Pedro, Colombo, Mario P., Di Virgilio, Francesco, Cavo, Michele, Adinolfi, Elena, Curti, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744438/
https://ncbi.nlm.nih.gov/pubmed/29312358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01918
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