Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells

Recent studies have shown that high ATP levels exhibit direct cytotoxic effects on several cancer cells types. Among the receptors engaged by ATP, P2×7R is the most consistently expressed by tumors. P2×7R is an ATP-gated ion channel that could drive the opening of a non-selective pore, triggering ce...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Salvestrini, Valentina, Orecchioni, Stefania, Talarico, Giovanna, Reggiani, Francesca, Mazzetti, Cristina, Bertolini, Francesco, Orioli, Elisa, Adinolfi, Elena, Virgilio, Francesco Di, Pezzi, Annalisa, Cavo, Michele, Lemoli, Roberto M, Curti, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351599/
https://ncbi.nlm.nih.gov/pubmed/27980223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13927
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