KIT D816 mutated/CBF-negative acute myeloid leukemia: a poor-risk subtype associated with systemic mastocytosis

KIT D816 mutations (KIT D816(mut)) are strongly associated with systemic mastocytosis (SM) but are also detectable in acute myeloid leukemia (AML), where they represent an adverse prognostic factor in combination with core binding factor (CBF) fusion genes. Here, we evaluated the clinical and molecu...

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Foilsithe in:Leukemia
Main Authors: Jawhar, Mohamad, Döhner, Konstanze, Kreil, Sebastian, Schwaab, Juliana, Shoumariyeh, Khalid, Meggendorfer, Manja, Span, Lambert L. F., Fuhrmann, Stephan, Naumann, Nicole, Horny, Hans-Peter, Sotlar, Karl, Kubuschok, Boris, von Bubnoff, Nikolas, Spiekermann, Karsten, Heuser, Michael, Metzgeroth, Georgia, Fabarius, Alice, Klein, Stefan, Hofmann, Wolf-Karsten, Kluin-Nelemans, Hanneke C., Haferlach, Torsten, Döhner, Hartmut, Cross, Nicholas C. P., Sperr, Wolfgang R., Valent, Peter, Reiter, Andreas
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756067/
https://ncbi.nlm.nih.gov/pubmed/30635631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0346-z
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