Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia

BCR-ABL+acute lymphoblastic leukemia (ALL) in adults has a poor prognosis with allogeneic stem cell transplantation (SCT) considered the best curative option for suitable patients. We here characterize the curative potential of BH3-mimetics differentially targeting mitochondrial BCL2-family members...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Scherr, Michaela, Kirchhoff, Hanna, Battmer, Karin, Wohlan, Katharina, Lee, Chun-Wei, Ricke-Hoch, Melanie, Erschow, Sergej, Law, Edward, Kloos, Arnold, Heuser, Michael, Ganser, Arnold, Hilfiker-Kleiner, Denise, Heidenreich, Olaf, Eder, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756054/
https://ncbi.nlm.nih.gov/pubmed/30546081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0315-6
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