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Leveraging protein dynamics to identify cancer mutational hotspots using 3D structures
Large-scale exome sequencing of tumors has enabled the identification of cancer drivers using recurrence-based approaches. Some of these methods also employ 3D protein structures to identify mutational hotspots in cancer-associated genes. In determining such mutational clusters in structures, existi...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6754584/ https://ncbi.nlm.nih.gov/pubmed/31462496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901156116 |
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