Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens

Queuosine (Q) is a complex tRNA modification widespread in eukaryotes and bacteria that contributes to the efficiency and accuracy of protein synthesis. Eukaryotes are not capable of Q synthesis and rely on salvage of the queuine base (q) as a Q precursor. While many bacteria are capable of Q de nov...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Yuan, Yifeng, Zallot, Rémi, Grove, Tyler L., Payan, Daniel J., Martin-Verstraete, Isabelle, Šepić, Sara, Balamkundu, Seetharamsingh, Neelakandan, Ramesh, Gadi, Vinod K., Liu, Chuan-Fa, Swairjo, Manal A., Dedon, Peter C., Almo, Steven C., Gerlt, John A., de Crécy-Lagard, Valérie
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2019
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PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754566/
https://ncbi.nlm.nih.gov/pubmed/31481610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909604116
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