Myc Is Required for Adaptive β-Cell Replication in Young Mice but Is Not Sufficient in One-Year-Old Mice Fed With a High-Fat Diet

Failure to expand pancreatic β-cells in response to metabolic stress leads to excessive workload resulting in β-cell dysfunction, dedifferentiation, death, and development of type 2 diabetes. In this study, we demonstrate that induction of Myc is required for increased pancreatic β-cell replication...

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Bibliografske podrobnosti
izdano v:Diabetes
Main Authors: Rosselot, Carolina, Kumar, Anil, Lakshmipathi, Jayalakshmi, Zhang, Pili, Lu, Geming, Katz, Liora S., Prochownik, Edward V., Stewart, Andrew F., Lambertini, Luca, Scott, Donald K., Garcia-Ocaña, Adolfo
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2019
Teme:
Islet Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754239/
https://ncbi.nlm.nih.gov/pubmed/31292135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-1368
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