Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase

Antimicrobial resistance is a global public threat and raises the need for development of new antibiotics with a novel mode of action. The dipeptidyl peptidase 11 from Porphyromonas gingivalis (PgDPP11) belongs to a new class of serine peptidases, family S46. Because S46 peptidases are not found in...

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Publicat a:Sci Rep
Autors principals: Sakamoto, Yasumitsu, Suzuki, Yoshiyuki, Nakamura, Akihiro, Watanabe, Yurie, Sekiya, Mizuki, Roppongi, Saori, Kushibiki, Chisato, Iizuka, Ippei, Tani, Osamu, Sakashita, Hitoshi, Inaka, Koji, Tanaka, Hiroaki, Yamada, Mitsugu, Ohta, Kazunori, Honma, Nobuyuki, Shida, Yosuke, Ogasawara, Wataru, Nakanishi-Matsui, Mayumi, Nonaka, Takamasa, Gouda, Hiroaki, Tanaka, Nobutada
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753110/
https://ncbi.nlm.nih.gov/pubmed/31537874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49984-3
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