The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

Macrophage-expressed gene 1 (MPEG1/Perforin-2) is a perforin-like protein that functions within the phagolysosome to damage engulfed microbes. MPEG1 is thought to form pores in target membranes, however, its mode of action remains unknown. We use cryo-Electron Microscopy (cryo-EM) to determine the 2...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Pang, Siew Siew, Bayly-Jones, Charles, Radjainia, Mazdak, Spicer, Bradley A., Law, Ruby H. P., Hodel, Adrian W., Parsons, Edward S., Ekkel, Susan M., Conroy, Paul J., Ramm, Georg, Venugopal, Hariprasad, Bird, Phillip I., Hoogenboom, Bart W., Voskoboinik, Ilia, Gambin, Yann, Sierecki, Emma, Dunstone, Michelle A., Whisstock, James C.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753088/
https://ncbi.nlm.nih.gov/pubmed/31537793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12279-2
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