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Identification and characterization of a novel heparan sulfate-binding domain in Activin A longest variants and implications for function

Activins regulate numerous processes including inflammation and are synthesized as precursors consisting of a long N-terminal pro-region and a mature protein. Genomic human databases currently list three activin A (Act A) variants termed X1, X2 and X3. The X3 variant is the shortest, lacks N-termina...

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Veröffentlicht in:PLoS One
Hauptverfasser: Yang, Evan, Mundy, Christina, Rappaport, Eric F., Pacifici, Maurizio, Billings, Paul C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752817/
https://ncbi.nlm.nih.gov/pubmed/31536599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222784
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