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Heparan sulfate antagonism alters bone morphogenetic protein signaling and receptor dynamics, suggesting a mechanism in hereditary multiple exostoses

Hereditary multiple exostoses (HME) is a pediatric disorder caused by heparan sulfate (HS) deficiency and is characterized by growth plate–associated osteochondromas. Previously, we found that osteochondroma formation in mouse models is preceded by ectopic bone morphogenetic protein (BMP) signaling...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mundy, Christina, Yang, Evan, Takano, Hajime, Billings, Paul C., Pacifici, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961057/
https://ncbi.nlm.nih.gov/pubmed/29622677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000264
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