CRISPR/Cas9-targeted enrichment and long-read sequencing of the Fuchs endothelial corneal dystrophy–associated TCF4 triplet repeat

PURPOSE: To demonstrate the utility of an amplification-free long-read sequencing method to characterize the Fuchs endothelial corneal dystrophy (FECD)-associated intronic TCF4 triplet repeat (CTG18.1). METHODS: We applied an amplification-free method, utilizing the CRISPR/Cas9 system, in combinatio...

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Xehetasun bibliografikoak
Argitaratua izan da:Genet Med
Egile Nagusiak: Hafford-Tear, Nathaniel J., Tsai, Yu-Chih, Sadan, Amanda N., Sanchez-Pintado, Beatriz, Zarouchlioti, Christina, Maher, Geoffrey J., Liskova, Petra, Tuft, Stephen J., Hardcastle, Alison J., Clark, Tyson A., Davidson, Alice E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group US 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752322/
https://ncbi.nlm.nih.gov/pubmed/30733599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-019-0453-x
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