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Epigenome editing strategies for the functional annotation of CTCF insulators
The human genome is folded into regulatory units termed ‘topologically-associated domains’ (TADs). Genome-wide studies support a global role for the insulator protein CTCF in mediating chromosomal looping and the topological constraint of TAD boundaries. However, the impact of individual insulators...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6751197/ https://ncbi.nlm.nih.gov/pubmed/31534142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12166-w |
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