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Salubrinal enhances eIF2α phosphorylation and improves fertility in a mouse model of Classic Galactosemia
Loss of galactose-1 phosphate uridylyltransferase (GALT) activity in humans results in Classic Galactosemia, and the GalT-deficient (GalT(−/−)) mouse mimics the patient condition. GalT(−/−) ovaries display elevated endoplasmic reticulum (ER) stress marker, BiP, and downregulated canonical phosphatid...
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| Publicado no: | Biochim Biophys Acta Mol Basis Dis |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6751024/ https://ncbi.nlm.nih.gov/pubmed/31362041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2019.07.010 |
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