Salubrinal enhances eIF2α phosphorylation and improves fertility in a mouse model of Classic Galactosemia

Loss of galactose-1 phosphate uridylyltransferase (GALT) activity in humans results in Classic Galactosemia, and the GalT-deficient (GalT(−/−)) mouse mimics the patient condition. GalT(−/−) ovaries display elevated endoplasmic reticulum (ER) stress marker, BiP, and downregulated canonical phosphatid...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochim Biophys Acta Mol Basis Dis
Prif Awduron: Balakrishnan, B, Siddiqi, A, Mella, J, Lupo, A, Li, E, Hollien, J, Johnson, J, Lai, K
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6751024/
https://ncbi.nlm.nih.gov/pubmed/31362041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2019.07.010
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