Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity

Hsp104 is an AAA+ protein disaggregase, which can be potentiated via diverse mutations in its autoregulatory middle domain (MD) to mitigate toxic misfolding of TDP-43, FUS, and α-synuclein implicated in fatal neurodegenerative disorders. Problematically, potentiated MD variants can exhibit off-targe...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cell Rep
Κύριοι συγγραφείς: Tariq, Amber, Lin, JiaBei, Jackrel, Meredith E., Hesketh, Christina D., Carman, Peter J., Mack, Korrie L., Weitzman, Rachel, Gambogi, Craig, Murillo, Oscar A. Hernandez, Sweeny, Elizabeth A., Gurpinar, Esin, Yokom, Adam L., Gates, Stephanie N., Yee, Keolamau, Sudesh, Saurabh, Stillman, Jacob, Rizo, Alexandra N., Southworth, Daniel R., Shorter, James
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2019
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750954/
https://ncbi.nlm.nih.gov/pubmed/31433984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.069
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