Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

Disrupting the interactions between Hsp90 and Cdc37 is emerging as an alternative and specific way to regulate the Hsp90 chaperone cycle in a manner not involving adenosine triphosphatase inhibition. Here, we identified DDO-5936 as a small-molecule inhibitor of the Hsp90-Cdc37 protein-protein intera...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Adv
Auteurs principaux: Wang, Lei, Zhang, Lixiao, Li, Li, Jiang, Jingsheng, Zheng, Zhen, Shang, Jialin, Wang, Chengxiang, Chen, Weilin, Bao, Qichao, Xu, Xiaoli, Jiang, Zhengyu, Zhang, Jian, You, Qidong
Format: Artigo
Langue:Inglês
Publié: American Association for the Advancement of Science 2019
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750927/
https://ncbi.nlm.nih.gov/pubmed/31555737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax2277
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