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Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases

[Image: see text] Microbial natural products are an important source of chemical entities for drug discovery. Recent advances in understanding the biosynthesis of secondary metabolites has revealed how this rich chemical diversity is generated through functional differentiation of biosynthetic enzym...

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Publicat a:ACS Chem Biol
Autors principals: Grocholski, Thadée, Yamada, Keith, Sinkkonen, Jari, Tirkkonen, Heli, Niemi, Jarmo, Metsä-Ketelä, Mikko
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750894/
https://ncbi.nlm.nih.gov/pubmed/30995392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00238
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