Transcription factor ID2 prevents E proteins from enforcing a naïve T lymphocyte gene program during NK cell development

All innate lymphoid cells (ILC) require the small helix-loop-helix transcription factor ID2 but the functions of ID2 are not well understood in these cells. Here we show that mature natural killer (NK) cells, the prototypic ILC, developed in mice lacking ID2 but remained as precursor CD27(+)CD11b(−)...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Zook, Erin C., Li, Zhong-Yin, Xu, Yiying, de Pooter, Renée F., Verykokakis, Mihalis, Beaulieu, Aimee, Lasorella, Anna, Maienschein-Cline, Mark, Sun, Joseph C., Sigvardsson, Mikael, Kee, Barbara L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750718/
https://ncbi.nlm.nih.gov/pubmed/29703840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aao2139
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