Autoantibodies to Killer Cell Immunoglobulin-Like Receptors in Patients With Systemic Lupus Erythematosus Induce Natural Killer Cell Hyporesponsiveness

Natural killer (NK) cell cytotoxicity toward self-cells is restrained by the inhibitory HLA class I-binding receptors CD94/NKG2A and the killer cell immunoglobulin-like receptors (KIRs). CD94/NKG2A and KIRs are also essential for NK cell education, which is a dynamic functional maturation process wh...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Segerberg, Filip, Lundtoft, Christian, Reid, Sarah, Hjorton, Karin, Leonard, Dag, Nordmark, Gunnel, Carlsten, Mattias, Hagberg, Niklas
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6749077/
https://ncbi.nlm.nih.gov/pubmed/31572377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02164
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