Enhanced Bone Marrow Homing of Natural Killer Cells Following mRNA Transfection With Gain-of-Function Variant CXCR4(R334X)

Adoptive transfer of natural killer (NK) cells can induce remission in patients with relapsed/refractory leukemia and myeloma. However, to date, clinical efficacy of NK cell immunotherapy has been limited to a sub-fraction of patients. Here we show that steps incorporated in the ex vivo manipulation...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Levy, Emily, Reger, Robert, Segerberg, Filip, Lambert, Melanie, Leijonhufvud, Caroline, Baumer, Yvonne, Carlsten, Mattias, Childs, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560173/
https://ncbi.nlm.nih.gov/pubmed/31231387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01262
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