Efficient mRNA-Based Genetic Engineering of Human NK Cells with High-Affinity CD16 and CCR7 Augments Rituximab-Induced ADCC against Lymphoma and Targets NK Cell Migration toward the Lymph Node-Associated Chemokine CCL19

For more than a decade, investigators have pursued methods to genetically engineer natural killer (NK) cells for use in clinical therapy against cancer. Despite considerable advances in viral transduction of hematopoietic stem cells and T cells, transduction efficiencies for NK cells have remained d...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Carlsten, Mattias, Levy, Emily, Karambelkar, Amrita, Li, Linhong, Reger, Robert, Berg, Maria, Peshwa, Madhusudan V., Childs, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801851/
https://ncbi.nlm.nih.gov/pubmed/27047492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00105
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