Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis

In normal conditions gut homeostasis is maintained by the suppressive activity of regulatory T cells (Tregs), characterized by the expression of the transcription factor FoxP3. In human inflammatory bowel disease, which is believed to be the consequence of the loss of tolerance toward antigens norma...

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Pubblicato in:Front Immunol
Autori principali: Di Giovangiulio, Martina, Rizzo, Angelamaria, Franzè, Eleonora, Caprioli, Flavio, Facciotti, Federica, Onali, Sara, Favale, Agnese, Stolfi, Carmine, Fehling, Hans-Joerg, Monteleone, Giovanni, Fantini, Massimo C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6749075/
https://ncbi.nlm.nih.gov/pubmed/31572375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02158
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