The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression

Expression of the mismatch repair gene MutL homolog 1 (MLH1) is silenced in a clinically important subgroup of sporadic colorectal cancers. These cancers exhibit hypermutability with microsatellite instability (MSI) and differ from microsatellite-stable (MSS) colorectal cancers in both prognosis and...

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Publicado no:Sci Rep
Main Authors: Thomas, Rachael, Trapani, Davide, Goodyer-Sait, Lily, Tomkova, Marketa, Fernandez-Rozadilla, Ceres, Sahnane, Nora, Woolley, Connor, Davis, Hayley, Chegwidden, Laura, Kriaucionis, Skirmantas, Maughan, Timothy, Leedham, Simon, Palles, Claire, Furlan, Daniela, Tomlinson, Ian, Lewis, Annabelle
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748923/
https://ncbi.nlm.nih.gov/pubmed/31530880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49952-x
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