The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression

Expression of the mismatch repair gene MutL homolog 1 (MLH1) is silenced in a clinically important subgroup of sporadic colorectal cancers. These cancers exhibit hypermutability with microsatellite instability (MSI) and differ from microsatellite-stable (MSS) colorectal cancers in both prognosis and...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Thomas, Rachael, Trapani, Davide, Goodyer-Sait, Lily, Tomkova, Marketa, Fernandez-Rozadilla, Ceres, Sahnane, Nora, Woolley, Connor, Davis, Hayley, Chegwidden, Laura, Kriaucionis, Skirmantas, Maughan, Timothy, Leedham, Simon, Palles, Claire, Furlan, Daniela, Tomlinson, Ian, Lewis, Annabelle
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748923/
https://ncbi.nlm.nih.gov/pubmed/31530880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49952-x
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars