The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability

Both colorectal (CRC, 15%) and endometrial cancers (EC, 30%) exhibit microsatellite instability (MSI) due to MLH1 hypermethylation and silencing. The MLH1 promoter polymorphism, rs1800734 is associated with MSI CRC risk, increased methylation and reduced MLH1 expression. In EC samples, we investigat...

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Bibliografiske detaljer
Udgivet i:Clin Epigenetics
Main Authors: Russell, Holly, Kedzierska, Katarzyna, Buchanan, Daniel D., Thomas, Rachael, Tham, Emma, Mints, Miriam, Keränen, Anne, Giles, Graham G., Southey, Melissa C., Milne, Roger L., Tomlinson, Ian, Church, David, Spurdle, Amanda B., O’Mara, Tracy A., Lewis, Annabelle
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346630/
https://ncbi.nlm.nih.gov/pubmed/32641106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00889-3
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