The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability

Both colorectal (CRC, 15%) and endometrial cancers (EC, 30%) exhibit microsatellite instability (MSI) due to MLH1 hypermethylation and silencing. The MLH1 promoter polymorphism, rs1800734 is associated with MSI CRC risk, increased methylation and reduced MLH1 expression. In EC samples, we investigat...

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Detaylı Bibliyografya
Yayımlandı:Clin Epigenetics
Asıl Yazarlar: Russell, Holly, Kedzierska, Katarzyna, Buchanan, Daniel D., Thomas, Rachael, Tham, Emma, Mints, Miriam, Keränen, Anne, Giles, Graham G., Southey, Melissa C., Milne, Roger L., Tomlinson, Ian, Church, David, Spurdle, Amanda B., O’Mara, Tracy A., Lewis, Annabelle
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2020
Konular:
Short Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346630/
https://ncbi.nlm.nih.gov/pubmed/32641106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00889-3
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