Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics

[Image: see text] Lens is the avascular tissue in the eye between the aqueous humor and vitreous. Drug binding to the lens might affect ocular pharmacokinetics, and the binding may also have a pharmacological role in drug-induced cataract and cataract treatment. Drug distribution in the lens has bee...

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Publié dans:Mol Pharm
Auteurs principaux: Heikkinen, Emma M., Auriola, Seppo, Ranta, Veli-Pekka, Demarais, Nicholas J., Grey, Angus C., del Amo, Eva M., Toropainen, Elisa, Vellonen, Kati-Sisko, Urtti, Arto, Ruponen, Marika
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2019
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748671/
https://ncbi.nlm.nih.gov/pubmed/31348666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00585
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