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Lafora Disease: A Review of Molecular Mechanisms and Pathology

Lafora’s disease is a neurodegenerative disorder caused by recessive loss-of-function mutations in the EPM2A (laforin glycogen phosphatase) or EPM2B (malin E3 ubiquitin ligase) genes. Neuropathology is characterized by malformed precipitated glycogen aggregates termed Lafora bodies. Asymptomatic unt...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuropediatrics
Prif Awduron: Verhalen, Brandy, Arnold, Susan, Minassian, Berge A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748624/
https://ncbi.nlm.nih.gov/pubmed/30336494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0038-1675238
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