A Novel Application of Mixed Effects Models for Reconciling Base-Pair Resolution 5-Methylcytosine and 5-Hydroxymethylcytosine Data in Neuroepigenetics

Epigenetic marks operate at multiple chromosomal levels to regulate gene expression, from direct covalent modification of DNA to three-dimensional chromosomal structure. Research has shown that 5-methylcytosine (5-mC) and its oxidized form, 5-hydroxymethylcytosine (5-hmC), are stable epigenetic mark...

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Bibliographische Detailangaben
Veröffentlicht in:Front Genet
Hauptverfasser: Kochmanski, Joseph, Savonen, Candace, Bernstein, Alison I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Genetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748167/
https://ncbi.nlm.nih.gov/pubmed/31552098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2019.00801
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