The Short N-Terminal Repeats of Transcription Termination Factor 1 Contain Semi-Redundant Nucleolar Localization Signals and P19-ARF Tumor Suppressor Binding Sites

The p14/p19(ARF) (ARF) tumor suppressor provides an important link in the activation of p53 (TP53) by inhibiting its targeted degradation via the E3 ligases MDM2/HDM2. However, ARF also limits tumor growth by directly inhibiting ribosomal RNA synthesis and processing. Initial studies of the ARF tumo...

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Publicado en:Yale J Biol Med
Autores principales: Boutin, Joël, Lessard, Frédéric, Tremblay, Michel G., Moss, Tom
Formato: Artigo
Lenguaje:Inglês
Publicado: YJBM 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6747939/
https://ncbi.nlm.nih.gov/pubmed/31543703
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