TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation

Elevated levels of IL-8 (CXCL8) in obesity have been linked with insulin resistance and type 2 diabetes (T2D). The mechanisms that lead to the profound production of IL-8 in obesity remains to be understood. TNF-α and saturated free fatty acids (FFAs) are increased in obese humans and correlate with...

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Pubblicato in:Int J Mol Sci
Autori principali: Hasan, Amal, Akhter, Nadeem, Al-Roub, Areej, Thomas, Reeby, Kochumon, Shihab, Wilson, Ajit, Koshy, Merin, Al-Ozairi, Ebaa, Al-Mulla, Fahd, Ahmad, Rasheed
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6747275/
https://ncbi.nlm.nih.gov/pubmed/31443599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20174112
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