An increased cell cycle gene network determines MEK and Akt inhibitor double resistance in triple-negative breast cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor clinical prognosis and limited targeted treatment strategies. Kinase inhibitor screening of a panel of 20 TNBC cell lines uncovered three critical TNBC subgroups: 1) sensitive to only MEK inhibitors; 2) sensitiv...

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Vydáno v:Sci Rep
Hlavní autoři: van der Noord, Vera E., McLaughlin, Ronan P., Smid, Marcel, Foekens, John A., Martens, John W. M., Zhang, Yinghui, van de Water, Bob
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746778/
https://ncbi.nlm.nih.gov/pubmed/31527768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49809-3
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