Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70)

Prion diseases are a group of incurable neurodegenerative disorders that affect humans and animals via infection with proteinaceous particles called prions. Prions are composed of PrP(Sc), a misfolded version of the cellular prion protein (PrP(C)). During disease progression, PrP(Sc) replicates by i...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mays, Charles E., Armijo, Enrique, Morales, Rodrigo, Kramm, Carlos, Flores, Andrea, Tiwari, Anjana, Bian, Jifeng, Telling, Glenn C., Pandita, Tej K., Hunt, Clayton R., Soto, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746463/
https://ncbi.nlm.nih.gov/pubmed/31320473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006186
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