Accelerated High Fidelity Prion Amplification Within and Across Prion Species Barriers

Experimental obstacles have impeded our ability to study prion transmission within and, more particularly, between species. Here, we used cervid prion protein expressed in brain extracts of transgenic mice, referred to as Tg(CerPrP), as a substrate for in vitro generation of chronic wasting disease...

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Bibliografiske detaljer
Main Authors: Green, Kristi M., Castilla, Joaquín, Seward, Tanya S., Napier, Dana L., Jewell, Jean E., Soto, Claudio, Telling, Glenn C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516356/
https://ncbi.nlm.nih.gov/pubmed/18769716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000139
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