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Accelerated High Fidelity Prion Amplification Within and Across Prion Species Barriers

Experimental obstacles have impeded our ability to study prion transmission within and, more particularly, between species. Here, we used cervid prion protein expressed in brain extracts of transgenic mice, referred to as Tg(CerPrP), as a substrate for in vitro generation of chronic wasting disease...

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Detalhes bibliográficos
Main Authors: Green, Kristi M., Castilla, Joaquín, Seward, Tanya S., Napier, Dana L., Jewell, Jean E., Soto, Claudio, Telling, Glenn C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516356/
https://ncbi.nlm.nih.gov/pubmed/18769716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000139
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