Prion Strain Mutation Determined by Prion Protein Conformational Compatibility and Primary Structure

Prions are infectious proteins composed of the abnormal disease-causing isoform PrP(Sc), which induces conformational conversion of the host-encoded normal cellular prion protein PrP(C) to additional PrP(Sc). The mechanism underlying prion strain mutation in the absence of nucleic acids remains unre...

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Main Authors: Angers, Rachel C., Kang, Hae-Eun, Napier, Dana, Browning, Shawn, Seward, Tanya, Mathiason, Candace, Balachandran, Aru, McKenzie, Debbie, Castilla, Joaquín, Soto, Claudio, Jewell, Jean, Graham, Catherine, Hoover, Edward A., Telling, Glenn C.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097672/
https://ncbi.nlm.nih.gov/pubmed/20466881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1187107
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