Hyaluronan synthase 2 (HAS2) overexpression diminishes the procatabolic activity of chondrocytes by a mechanism independent of extracellular hyaluronan

Osteoarthritis (OA) is a progressive degenerative disease of the joints caused in part by a change in the phenotype of resident chondrocytes within affected joints. This altered phenotype, often termed proinflammatory or procatabolic, features enhanced production of endoproteinases and matrix metall...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Ishizuka, Shinya, Tsuchiya, Saho, Ohashi, Yoshifumi, Terabe, Kenya, Askew, Emily B., Ishizuka, Naoko, Knudson, Cheryl B., Knudson, Warren
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2019
Предметы:
Glycobiology and Extracellular Matrices
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746454/
https://ncbi.nlm.nih.gov/pubmed/31270213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008567
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