Nonnative structure in a peptide model of the unfolded state of superoxide dismutase 1 (SOD1): Implications for ALS-linked aggregation

Dozens of mutations throughout the sequence of the gene encoding superoxide dismutase 1 (SOD1) have been linked to toxic protein aggregation in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). A parsimonious explanation for numerous genotypes resulting in a common phenotype would b...

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Опубликовано в: :J Biol Chem
Главные авторы: Cohen, Noah R., Zitzewitz, Jill A., Bilsel, Osman, Matthews, C. Robert
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2019
Предметы:
Molecular Biophysics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746449/
https://ncbi.nlm.nih.gov/pubmed/31341015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008765
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