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Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity

Neurodegenerative diseases constitute a class of illnesses marked by pathological protein aggregation in the brains of affected individuals. Although these disorders are invariably characterized by the degeneration of highly specific subpopulations of neurons, protein aggregation occurs in all cells...

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Detalhes bibliográficos
Main Authors: Weisberg, Sarah J., Lyakhovetsky, Roman, Werdiger, Ayelet-chen, Gitler, Aaron D., Soen, Yoav, Kaganovich, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465386/
https://ncbi.nlm.nih.gov/pubmed/22967507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205829109
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