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S100A6 Amyloid Fibril Formation Is Calcium-modulated and Enhances Superoxide Dismutase-1 (SOD1) Aggregation

S100A6 is a small EF-hand calcium- and zinc-binding protein involved in the regulation of cell proliferation and cytoskeletal dynamics. It is overexpressed in neurodegenerative disorders and a proposed marker for Amyotrophic Lateral Sclerosis (ALS). Following recent reports of amyloid formation by S...

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Detalhes bibliográficos
Main Authors: Botelho, Hugo M., Leal, Sónia S., Cardoso, Isabel, Yanamandra, Kiran, Morozova-Roche, Ludmilla A., Fritz, Günter, Gomes, Cláudio M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516767/
https://ncbi.nlm.nih.gov/pubmed/23076148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.396416
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