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Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells
Cytotoxic T lymphocytes (CTLs) kill by forming immunological synapses with target cells and secreting toxic proteases and the pore forming protein perforin into the intercellular space. Immunological synapses are highly dynamic structures that boost perforin activity by applying mechanical force aga...
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| Publicado en: | Sci Immunol |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6746172/ https://ncbi.nlm.nih.gov/pubmed/30902904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aav5445 |
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