LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone

Despite recent advances, the myeloproliferative neoplasms (MPNs) are attended by considerable morbidity and mortality. Janus kinase (Jak) inhibitors such as ruxolitinib manage symptoms but do not substantially change the natural history of the disease. In this report, we show the effects of IMG-7289...

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Detalhes bibliográficos
Publicado no:Hemasphere
Main Authors: Jutzi, Jonas S., Kleppe, Maria, Dias, Jennifer, Staehle, Hans Felix, Shank, Kaitlyn, Teruya-Feldstein, Julie, Gambheer, Sudheer Madan Mohan, Dierks, Christine, Rienhoff, Hugh Y., Levine, Ross L., Pahl, Heike L.
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Health 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745991/
https://ncbi.nlm.nih.gov/pubmed/31723778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HS9.0000000000000054
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