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In Vitro and in Vivo antitumor activity and the mechanism of siphonodictyal B in human colon cancer cells

Liphagal, isolated from the marine sponge Aka coralliphaga, exhibits phosphatidylinositol 3‐kinase alpha (PI3Kα) inhibitory activity and cytotoxic effects in human cancer cells. Siphonodictyal B, the biogenetic precursor of liphagal, also has PI3K inhibitory activity. However, its cytotoxic or antit...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Chikamatsu, Sonoko, Saijo, Ken, Imai, Hiroo, Narita, Koichi, Kawamura, Yoshifumi, Katoh, Tadashi, Ishioka, Chikashi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745845/
https://ncbi.nlm.nih.gov/pubmed/31364822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2409
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