Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain

Neonatal seizures disrupt normal synaptic maturation and often lead to later-life epilepsy and cognitive deficits. During early life, the brain exhibits heightened synaptic plasticity, in part due to a developmental over-abundance of Ca(V)1.2 L-type voltage gated calcium (Ca(2+)) channels (LT-VGCCs)...

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Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Rosenberg, Evan C., Lippman-Bell, Jocelyn J., Handy, Marcus, Soldan, Samantha S., Rakhade, Sanjay, Hilario-Gomez, Cristina, Folweiler, Kaitlyn, Jacobs, Leah, Jensen, Frances E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745700/
https://ncbi.nlm.nih.gov/pubmed/29738885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.05.001
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