Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation

Ovarian toxicity and infertility are major side effects of cancer therapy in young female cancer patients. We and others have previously demonstrated that doxorubicin (DOX), one of the most widely used chemotherapeutic chemicals, has a dose-dependent toxicity on growing follicles. However, it is not...

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Vydáno v:Toxicol Appl Pharmacol
Hlavní autoři: Wang, Yingzheng, Liu, Mingjun, Johnson, Sarah B., Yuan, Gehui, Arriba, Alana K., Zubizarreta, Maria E., Chatterjee, Saurabh, Nagarkatti, Mitzi, Nagarkatti, Prakash, Xiao, Shuo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745286/
https://ncbi.nlm.nih.gov/pubmed/31437492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2019.114714
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