Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation

Ovarian toxicity and infertility are major side effects of cancer therapy in young female cancer patients. We and others have previously demonstrated that doxorubicin (DOX), one of the most widely used chemotherapeutic chemicals, has a dose-dependent toxicity on growing follicles. However, it is not...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Wang, Yingzheng, Liu, Mingjun, Johnson, Sarah B., Yuan, Gehui, Arriba, Alana K., Zubizarreta, Maria E., Chatterjee, Saurabh, Nagarkatti, Mitzi, Nagarkatti, Prakash, Xiao, Shuo
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745286/
https://ncbi.nlm.nih.gov/pubmed/31437492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2019.114714
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