Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice

Cisplatin is a first-line chemotherapeutic agent for ovarian cancer that acts by promoting DNA cross links and adduct. However drug resistance and considerable side effects including reproductive toxicity remain a significant challenge. PTEN is well known as a tumor suppressor function which plays a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chang, Eun Mi, Lim, Eunjin, Yoon, Sookyoung, Jeong, Kyungah, Bae, Sijeong, Lee, Dong Ryul, Yoon, Tae Ki, Choi, Youngsok, Lee, Woo Sik
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699462/
https://ncbi.nlm.nih.gov/pubmed/26656301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0144245
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