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Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction
A hallmark of cancer is genomic instability, which can enable cancer cells to evade therapeutic strategies. Here we employed a computational approach to uncover mechanisms underlying cancer mutational burden by focusing upon relationships between 1) translocation breakpoints and the thousands of G4...
Shranjeno v:
| izdano v: | Prog Biophys Mol Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6745008/ https://ncbi.nlm.nih.gov/pubmed/30880007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbiomolbio.2019.03.004 |
| Oznake: |
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