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Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction

A hallmark of cancer is genomic instability, which can enable cancer cells to evade therapeutic strategies. Here we employed a computational approach to uncover mechanisms underlying cancer mutational burden by focusing upon relationships between 1) translocation breakpoints and the thousands of G4...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Prog Biophys Mol Biol
Main Authors: Bacolla, Albino, Ye, Zu, Ahmed, Zamal, Tainer, John A.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745008/
https://ncbi.nlm.nih.gov/pubmed/30880007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbiomolbio.2019.03.004
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