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Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes
Mitochondrial DNA (mtDNA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair system. This explains an increased mutation rate of mtDNA that results in heteroplasmy, e.g., the coexistence of the mutant and wild-type mtDNA molecules within the same mitochond...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Baishideng Publishing Group Co., Limited
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3364501/ https://ncbi.nlm.nih.gov/pubmed/22655163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4330/wjc.v4.i5.148 |
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